Pietraszek M H, Takada Y, Takada A
Department of Physiology, Hamamatsu University School of Medicine, Japan.
Haemostasis. 1991;21(6):346-52. doi: 10.1159/000216248.
The present study was aimed at testing the hypothesis about the relation between mental stress and platelet function. Plasma samples were obtained from 100 students immediately before, and 30 min and 7 h after undergoing a bleeding time test, which was used as mental stressor. Platelet responses to serotonin, ADP and collagen, as well as plasma catecholamine levels were assayed. Plasma serotonin levels had a high negative correlation with the bleeding time. Stress resulted in an increase in platelet responses to serotonin, ADP and to the elevation of catecholamine levels. Furthermore, a significant negative correlation between the platelet aggregation induced by ADP and collagen and the bleeding time was demonstrated. It is concluded that mental stress had a significant effect on platelet aggregation. This study provides evidence of increased platelet aggregability in association with elevated plasma catecholamine levels.
本研究旨在验证关于心理应激与血小板功能之间关系的假说。从100名学生身上采集血浆样本，分别在他们接受作为心理应激源的出血时间测试之前、测试后30分钟和7小时进行。检测血小板对5-羟色胺、二磷酸腺苷（ADP）和胶原的反应以及血浆儿茶酚胺水平。血浆5-羟色胺水平与出血时间呈高度负相关。应激导致血小板对5-羟色胺、ADP的反应增加以及儿茶酚胺水平升高。此外，还证实ADP和胶原诱导的血小板聚集与出血时间之间存在显著负相关。得出的结论是，心理应激对血小板聚集有显著影响。本研究提供了与血浆儿茶酚胺水平升高相关的血小板聚集性增加的证据。
