Naesh O, Hindberg I, Trap-Jensen J, Lund J O
Department of Clinical Physiology/Nuclear Medicine, Frederiksberg Hospital, Copenhagen, Denmark.
Clin Physiol. 1990 May;10(3):221-30. doi: 10.1111/j.1475-097x.1990.tb00090.x.
Relatively scarce information is found on the period immediately following physical stress, with special reference to human platelet activity. This, in connection with earlier observations of an increase in platelet release products and hyperaggregability following surgical stress, has initiated the present study. We studied platelet function in eight healthy non-mediated volunteers during and 1 h after cycle exercise of submaximal intensity. ADP-induced platelet aggregability was enhanced in the last minute of exercise followed by a decreased aggregability 1 h after. Adrenaline-induced platelet aggregation showed the same attenuation after exercise but no change during work. The release products beta-thromboglobulin and serotonin in plasma showed significant increases after exercise. This is taken as evidence of an enhanced platelet activity following exercise. A normal stress-response, measured as increase in cyclic AMP in plasma, was observed. In conclusion, platelets are activated following moderate exercise and it seems valid to include the post-exercise period in future studies.
关于身体应激后紧接着的这段时期，特别是关于人体血小板活性的信息相对较少。这与早期观察到的手术应激后血小板释放产物增加和高聚集性有关，从而启动了本研究。我们研究了8名健康的非运动志愿者在次最大强度循环运动期间及运动后1小时的血小板功能。在运动的最后一分钟，ADP诱导的血小板聚集性增强，随后在运动后1小时聚集性降低。肾上腺素诱导的血小板聚集在运动后也表现出相同的减弱，但在运动期间没有变化。血浆中的释放产物β-血小板球蛋白和血清素在运动后显著增加。这被视为运动后血小板活性增强的证据。观察到以血浆中环磷酸腺苷增加来衡量的正常应激反应。总之，适度运动后血小板被激活，在未来的研究中纳入运动后时期似乎是合理的。
