Avkiran Metin, Rowland Alexandra J, Cuello Friederike, Haworth Robert S
Cardiovascular Division, King's College London, The Rayne Institute, St Thomas' Hospital, London SE1 7EH, United Kingdom.
Circ Res. 2008 Feb 1;102(2):157-63. doi: 10.1161/CIRCRESAHA.107.168211.
The protein kinase D (PKD) family is a recent addition to the calcium/calmodulin-dependent protein kinase group of serine/threonine kinases, within the protein kinase complement of the mammalian genome. Relative to their alphabetically superior cousins in the AGC group of kinases, namely the various isoforms of protein kinase A, protein kinase B/Akt, and protein kinase C, PKD family members have to date received limited attention from cardiovascular investigators. Nevertheless, increasing evidence now points toward important roles for PKD-mediated signaling pathways in the cardiovascular system, particularly in the regulation of myocardial contraction, hypertrophy and remodeling. This review provides a primer on PKD signaling, using information gained from studies in multiple cell types, and discusses recent data that suggest novel functions for PKD-mediated pathways in the heart and the circulation.
蛋白激酶D（PKD）家族是哺乳动物基因组蛋白激酶补充体系中，丝氨酸/苏氨酸激酶的钙/钙调蛋白依赖性蛋白激酶组中的新成员。相对于激酶AGC组中按字母顺序排在前面的同类蛋白，即蛋白激酶A、蛋白激酶B/Akt和蛋白激酶C的各种亚型，PKD家族成员迄今为止受到心血管研究人员的关注有限。然而，越来越多的证据表明PKD介导的信号通路在心血管系统中发挥重要作用，尤其是在心肌收缩、肥大和重塑的调节方面。本综述利用从多种细胞类型研究中获得的信息，对PKD信号传导进行了初步介绍，并讨论了近期数据，这些数据表明PKD介导的通路在心脏和循环系统中具有新功能。
