Nahab Fadi, Cotsonis George, Lynn Michael, Feldmann Edward, Chaturvedi Seemant, Hemphill J Claude, Zweifler Richard, Johnston Karen, Bonovich David, Kasner Scott, Chimowitz Marc
Stroke. 2008 Mar;39(3):1039-41. doi: 10.1161/STROKEAHA.107.499475. Epub 2008 Jan 31.
There are limited data on the prevalence and prognosis of asymptomatic intracranial stenosis (AIS).
Baseline cerebral angiograms and MR angiograms were used to determine AIS (50% to 99%) coexistent to symptomatic intracranial stenosis for patients enrolled in the Warfarin-Aspirin Symptomatic Intracranial Disease study.
Coexisting AIS were detected in 18.9% (n=14/74) of patients undergoing 4-vessel cerebral angiography and 27.3% (n=65/238) of patients undergoing MR angiogram. During a mean follow-up period of 1.8 years, no ischemic strokes were attributable to an AIS on cerebral angiography and 5 ischemic strokes (5.9%, 95% CI: 2.1% to 12.3%) occurred in the AIS territory on MR angiogram (risk at 1 year=3.5%, 95% CI: 0.8% to 9.0%).
Whereas the prevalence of coexisting AIS (50% to 99%) in patients with symptomatic stenosis is high, the risk of stroke from these asymptomatic stenoses is low.
关于无症状颅内狭窄（AIS）的患病率和预后的数据有限。
对于参加华法林 - 阿司匹林治疗有症状颅内疾病研究的患者，使用基线脑血管造影和磁共振血管造影来确定与有症状颅内狭窄并存的AIS（50%至99%）。
在接受四血管脑血管造影的患者中，18.9%（n = 14/74）检测到并存AIS，在接受磁共振血管造影的患者中，27.3%（n = 65/238）检测到并存AIS。在平均1.8年的随访期内，脑血管造影上无缺血性卒中归因于AIS，而在磁共振血管造影上，5例缺血性卒中（5.9%，95%CI：2.1%至12.3%）发生在AIS区域（1年风险 = 3.5%，95%CI：0.8%至9.0%）。
有症状狭窄患者中并存AIS（50%至99%）的患病率较高，但这些无症状狭窄导致卒中的风险较低。
