Rózewicka L, Barcew-Wiszniewska B, Wójcicki J, Samochowiec L, Krasowska B
Department of Histology and Embrology, Medical Academy, Szczecin, Poland.
Kitasato Arch Exp Med. 1991 Dec;64(4):183-92.
The effect of selenium and vitamin E on lipid level in the blood serum, on the oxygen free radicals generation and on morphology of heart was tested after separate and combined administration to mongrel male rabbits fed on a high-fat diet (HFD). The lipid level and oxygen free radical generation was depressed markedly in animals fed on a HFD and receiving simultaneously selenium and vitamin E. In animals on a HFD the walls of the heart vessels were thickened, always to their complete obliteration. The presence of lipid droplets in endocardium could be observed as well. The hearts of the rabbits receiving selenium showed markedly fewer atheromatously changed vessels. Moreover, no accumulation of lipid droplets was seen in the endocardium of these animals. The least atherosclerotic alterations were observed in the myocardium of rabbits given HFD with addition of selenium and vitamin E in combination, no accumulation of lipids was shown in endocardium of these rabbits. An important finding of this study is, that the combination of selenium and vitamin E results in an intensified protective effect against changes evoked in the heart muscle of rabbits fed on a HFD.
在给高脂饮食（HFD）喂养的杂种雄性兔子分别单独及联合给予硒和维生素E后，检测了它们对血清脂质水平、氧自由基生成及心脏形态的影响。在高脂饮食且同时接受硒和维生素E的动物中，脂质水平和氧自由基生成显著降低。在高脂饮食的动物中，心脏血管壁增厚，直至完全闭塞。在心内膜中也可观察到脂滴的存在。接受硒的兔子心脏中，动脉粥样硬化改变的血管明显较少。此外，在这些动物的心内膜中未见到脂滴积聚。在给予添加了硒和维生素E组合的高脂饮食的兔子心肌中，观察到的动脉粥样硬化改变最少，这些兔子的心内膜中未显示脂质积聚。本研究的一个重要发现是，硒和维生素E的组合对高脂饮食喂养的兔子心肌中所引发的变化产生增强的保护作用。
