Rawat Manju, Singh Deependra, Saraf S, Saraf Swarnlata
Institute of Pharmacy, Pt Ravishankar Shukla University, Raipur, India.
Yakugaku Zasshi. 2008 Feb;128(2):269-80. doi: 10.1248/yakushi.128.269.
Lipid based carriers have attracted increasing scientific and commercial attention during the last few years as an alternative material for the delivery of peptides and proteins concerned with stability issues. This article presents an overview of different types of biocompatible and versatile lipid-based carriers employed for the delivery of therapeutic proteins and peptides. Such delivery systems are discussed and exemplified regarding both more traditional lipid based delivery systems such as liposomes and lipid emulsions as well as more novel structures, e.g., lipid microtubules, microbubbles, and solid lipid nanoparticles.
在过去几年中,基于脂质的载体作为一种解决肽和蛋白质稳定性问题的替代材料,已引起越来越多的科学和商业关注。本文概述了用于递送治疗性蛋白质和肽的不同类型的生物相容性和多功能脂质载体。文中讨论并举例说明了此类递送系统,包括更传统的基于脂质的递送系统,如脂质体和脂质乳剂,以及更新颖的结构,如脂质微管、微泡和固体脂质纳米粒。