Mehanna Mohammed M, Mneimneh Amina Tarek
Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon.
Adv Pharm Bull. 2021 Jan;11(1):56-67. doi: 10.34172/apb.2021.006. Epub 2020 Nov 7.
The drug delivery investigation field is continuously widened and adapted to overcome many factors such as poor drug solubility, absorption, rapid metabolism, the variability of drug plasma levels, cellular efflux and many others. Due to resemblance to body constituents and their biocompatibility, lipids offer a promising scheme for poorly water-soluble and lipophilic drugs. Various nanoparticles including vesicular systems, lipid particulate systems, and emulsion systems provide some unique benefits as pharmaceutical carriers in drug and biomolecules delivery systems. Nowadays synthesis is directed toward simple, costless techniques, therefore, self-emulsifying systems have gained superiority over the other carriers. Self nano-emulsifying systems composed of oil, surfactant, and co-surfactant emulsified upon contact with an aqueous medium, has been widely exploited. This review attempts to provide a comprehensive interpretation of different types of lipid-based carriers emphasizing on the self-nanoemulsifying system, why it is gaining interest, formulation, composition, and applications.
药物递送研究领域在不断拓展并进行调整，以克服诸多因素，如药物溶解度差、吸收困难、代谢迅速、药物血浆水平的变异性、细胞外排等。由于脂质与人体成分相似且具有生物相容性，因此为水溶性差的亲脂性药物提供了一种有前景的方案。包括囊泡系统、脂质颗粒系统和乳液系统在内的各种纳米颗粒，在药物和生物分子递送系统中作为药物载体具有一些独特的优势。如今，合成方法正朝着简单、低成本的技术发展，因此，自乳化系统已比其他载体更具优势。由油、表面活性剂和助表面活性剂组成的自纳米乳化系统在与水性介质接触时会乳化，已得到广泛应用。本综述试图对不同类型的脂质基载体进行全面解读，重点是自纳米乳化系统，解释其为何受到关注、制剂、组成和应用。
