Hjelmborg Jacob v B, Fagnani Corrado, Silventoinen Karri, McGue Matt, Korkeila Maarit, Christensen Kaare, Rissanen Aila, Kaprio Jaakko
Statistics and Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Obesity (Silver Spring). 2008 Apr;16(4):847-52. doi: 10.1038/oby.2007.135. Epub 2008 Jan 31.
To investigate the interplay between genetic factors influencing baseline level and changes in BMI in adulthood.
A longitudinal twin study of the cohort of Finnish twins (N = 10,556 twin individuals) aged 20-46 years at baseline was conducted and followed up 15 years. Data on weight and height were obtained from mailed surveys in 1975, 1981, and 1990.
Latent growth models revealed a substantial genetic influence on BMI level at baseline in males and females (heritability (h(2)) 80% (95% confidence interval 0.79-0.80) for males and h(2) = 82% (0.81, 0.84) for females) and a moderate-to-high influence on rate of change in BMI (h(2) = 58% (0.50, 0.69) for males and h(2) = 64% (0.58, 0.69) for females). Only very weak evidence for genetic pleiotropy was observed; the genetic correlation between baseline and rate of change in BMI was very modest (-0.070 (-0.13, -0.068) for males and 0.04 (0.00, 0.08) for females.
Our population-based results provide a basis for identifying genetic variants for change in BMI, in particular weight gain. Furthermore, they demonstrate for the first time that such genetic variants for change in BMI are likely to be different from those affecting level of BMI.
研究影响成年期BMI基线水平及变化的遗传因素之间的相互作用。
对基线年龄为20 - 46岁的芬兰双胞胎队列（N = 10556名双胞胎个体）进行纵向双胞胎研究，并随访15年。体重和身高数据来自1975年、1981年和1990年的邮寄调查。
潜在生长模型显示，遗传因素对男性和女性BMI基线水平有重大影响（男性遗传度（h(2)）为80%（95%置信区间0.79 - 0.80），女性h(2) = 82%（0.81, 0.84）），对BMI变化率有中度至高度影响（男性h(2) = 58%（0.50, 0.69），女性h(2) = 64%（0.58, 0.69））。仅观察到非常微弱的基因多效性证据；BMI基线与变化率之间的遗传相关性非常小（男性为-0.070（-0.13, -0.068），女性为0.04（0.00, 0.08））。
我们基于人群的研究结果为识别BMI变化（特别是体重增加）的遗传变异提供了基础。此外，它们首次证明，这种BMI变化的遗传变异可能与影响BMI水平的遗传变异不同。
