Obesity Research Unit, Department of Medicine, Division of Internal Medicine and Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland.
Int J Obes (Lond). 2012 Mar;36(3):456-64. doi: 10.1038/ijo.2011.160. Epub 2011 Aug 9.
To investigate whether the paradoxical weight gain associated with dieting is better related to genetic propensity to weight gain than to the weight loss episodes themselves.
Subjects included 4129 individual twins from the population-based FinnTwin16 study (90% of twins born in Finland 1975-1979). Weight and height were obtained from longitudinal surveys at 16, 17, 18 and 25 years, and number of lifetime intentional weight loss (IWL) episodes of more than 5 kg at 25 years.
IWLs predicted accelerated weight gain and risk of overweight. The odds of becoming overweight (body mass index (BMI)≥ 25 kg m(-2)) by 25 years were significantly greater in subjects with one (OR 1.8, 95% CI 1.3-2.6, and OR 2.7, 1.7-4.3 in males and females, respectively), or two or more (OR 2.0, 1.3-3.3, and OR 5.2, 3.2-8.6, in males and females, respectively), IWLs compared with subjects with no IWL. In MZ pairs discordant for IWL, co-twins with at least one IWL were 0.4 kg m(-2) (P=0.041) heavier at 25 years than their non-dieting co-twins (no differences in baseline BMIs). In DZ pairs, co-twins with IWLs gained progressively more weight than non-dieting co-twins (BMI difference 1.7 kg m(-2) at 16 years and 2.2 kg m(-2) at 25 years, P<0.001).
Our results suggest that frequent IWLs reflect susceptibility to weight gain, rendering dieters prone to future weight gain. The results from the MZ pairs discordant for IWLs suggest that dieting itself may induce a small subsequent weight gain, independent of genetic factors.
研究与节食相关的矛盾性体重增加是否与体重增加的遗传倾向有关，而不是与减肥本身有关。
本研究对象为基于人群的芬兰双胞胎 16 研究（1975-1979 年芬兰出生的双胞胎中 90%）中的 4129 名个体双胞胎。体重和身高来自于 16、17、18 和 25 岁时的纵向调查，以及 25 岁时超过 5 公斤的终生有意减肥（IWL）次数。
IWL 预测体重加速增加和超重风险。与没有 IWL 的受试者相比，有一次（OR 1.8，95%CI 1.3-2.6，男性和女性分别为 OR 2.7，1.7-4.3）或两次或更多次（OR 2.0，1.3-3.3，男性和女性分别为 OR 5.2，3.2-8.6）的 IWL 受试者，25 岁时超重的几率显著增加（男性和女性）。在 IWL 不一致的 MZ 对中，至少有一次 IWL 的双胞胎在 25 岁时比他们不节食的双胞胎重 0.4 公斤/米（P=0.041）。在 DZ 对中，有 IWL 的双胞胎比没有 IWL 的双胞胎体重增加更多（16 岁时体重差异 1.7 公斤/米，25 岁时体重差异 2.2 公斤/米，P<0.001）。
我们的研究结果表明，频繁的 IWL 反映了对体重增加的易感性，使节食者容易出现未来的体重增加。IWL 不一致的 MZ 对的结果表明，节食本身可能会导致随后的体重轻微增加，而与遗传因素无关。
