Sandhofer Anton, Tatarczyk Tobias, Laimer Markus, Ritsch Andreas, Kaser Susanne, Paulweber Bernhard, Ebenbichler Christoph F, Patsch Josef R
Clinical Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse, Innsbruck, Austria.
Obesity (Silver Spring). 2008 Apr;16(4):919-22. doi: 10.1038/oby.2007.130. Epub 2008 Jan 24.
The metabolic syndrome is associated with low high-density lipoprotein-cholesterol (HDL-C) and decreased low-density lipoprotein (LDL) particle size. The Taq1B-polymorphism in the cholesteryl ester-transfer protein (CETP)-gene influences HDL-C, CETP concentration, and LDL-size. We investigated the effect of the Taq1B-polymorphism on the risk of the metabolic syndrome in 1,503 participants (973 men, 530 women) of the Salzburg Atherosclerosis Prevention program in subjects at High Individual Risk study. CETP concentration was determined in a subgroup (n = 486) by an enzyme-linked immunosorbent assay. Prevalence of the metabolic syndrome was 16.7% (18.5% in men, 13.5% in women). The Taq1B-polymorphism influenced significantly CETP concentrations, HDL-C levels, and LDL-size (P < 0.001 for all). The relative risk of the metabolic syndrome was reduced by 32% (odds ratio (OR) 0.68 (95% CI: 0.51-0.89), P = 0.005) in carriers of the B2 variant. This risk reduction persisted after adjustment for age and sex (OR 0.69 (0.53-0.92), P = 0.01) and after further adjustment for body mass index, waist-to-hip ratio, blood pressure, insulin resistance (IR), HDL-C, and triglycerides (TGs) (OR 0.43 (0.26-0.72), P = 0.001). Furthermore, the risk reduction was more pronounced in men than in women. We conclude that CETP plays an important role in the metabolic syndrome, possibly involving novel functions of CETP.
代谢综合征与低高密度脂蛋白胆固醇（HDL-C）以及低密度脂蛋白（LDL）颗粒大小减小有关。胆固醇酯转运蛋白（CETP）基因中的Taq1B多态性会影响HDL-C、CETP浓度和LDL大小。我们在萨尔茨堡动脉粥样硬化预防项目中针对高个体风险研究的1503名参与者（973名男性，530名女性）调查了Taq1B多态性对代谢综合征风险的影响。通过酶联免疫吸附测定法在一个亚组（n = 486）中测定CETP浓度。代谢综合征的患病率为16.7%（男性为18.5%，女性为13.5%）。Taq1B多态性显著影响CETP浓度、HDL-C水平和LDL大小（所有P值均<0.001）。B2变异携带者的代谢综合征相对风险降低了32%（优势比（OR）为0.68（95%置信区间：0.51 - 0.89），P = 0.005）。在调整年龄和性别后（OR为0.69（0.53 - 0.92），P = 0.01）以及在进一步调整体重指数、腰臀比、血压、胰岛素抵抗（IR）、HDL-C和甘油三酯（TGs）后（OR为0.43（0.26 - 0.72），P = 0.001），这种风险降低仍然存在。此外，男性的风险降低比女性更明显。我们得出结论，CETP在代谢综合征中起重要作用，可能涉及CETP的新功能。
