中国新疆维吾尔族成年人中六种胆固醇酯转运蛋白基因多态性与代谢综合征的关联
Association between Six CETP Polymorphisms and Metabolic Syndrome in Uyghur Adults from Xinjiang, China.
作者信息
Hou Huixian, Ma Rulin, Guo Heng, He Jia, Hu Yunhua, Mu Lati, Yan Yizhong, Ma Jiaolong, Li Shugang, Zhang Jingyu, Ding Yusong, Zhang Mei, Niu Qiang, Liu Jiaming, Guo Shuxia
机构信息
Department of Public Health and Key Laboratory of Xinjiang Endemic and Ethnic Diseases of the Ministry of Education, Shihezi University School of Medicine, Shihezi 832002, China.
出版信息
Int J Environ Res Public Health. 2017 Jun 18;14(6):653. doi: 10.3390/ijerph14060653.
OBJECTIVE
To explore the association between gene polymorphisms and metabolic syndrome (MS), as well as the relationship between the gene polymorphisms and each component of MS.
METHODS
A total of 571 individuals which were randomly selected from 5692 Uyghur adults were subdivided into two groups, including 280 patients with MS and 291 control subjects, using the group-matching method after matching for gender. We detected polymorphisms (rs5882, rs1800775, rs3764261, rs12149545, rs711752, and rs708272) by using the Snapshot method.
RESULTS
(1) Significant differences were found involving the frequency distribution of genotypes and alleles of rs1800775, rs3764261, rs12149545, rs711752, and rs708272 between the control and MS groups (all < 0.05). (2) rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms were significantly related to the risk of MS (all < 0.05). (3) The rs1800775 polymorphism was associated with high fasting blood glucose levels and low high density lipoprotein cholesterol (HDL-C); rs3764261 and rs12149545 polymorphisms were associated with all components of MS except high blood pressure; rs711752 and rs708272 polymorphisms were associated with low HDL-C (all < 0.05). (4) Complete linkage disequilibrium (LD) was identified for two pairs of single nucleotide polymorphisms (SNPs) (rs3764261 and rs12149545 (D' = 1.000, r² = 0.931), rs711752 and rs708272 (D' = 1.000, r² = 0.996)). (5) The A-G-G-G-C ( = 0.013, odds ratio [OR] = 0.622, 95% confidence interval [95% CI] = 0.427-0.906) and A-T-A-A-T ( < 0.001, OR = 0.519, 95% CI = 0.386-0.697) haplotypes were more frequent in the control group than in the case group. : The rs1800775, rs3764261, rs12149545, rs711752, and rs708272 polymorphisms of were associated with MS and its components among the Uyghur ethnic group. Complete LD was found between two pairs of SNPs (rs3764261 and rs12149545, rs711752, and rs708272). The A-G-G-G-C and A-T-A-A-T haplotypes might be protective factors for MS.
目的
探讨基因多态性与代谢综合征（MS）之间的关联，以及基因多态性与MS各组分之间的关系。
方法
从5692名维吾尔族成年人中随机选取571例个体，采用组内匹配法按性别匹配后分为两组，包括280例MS患者和291例对照者。采用Snapshot法检测基因多态性（rs5882、rs1800775、rs3764261、rs12149545、rs711752和rs708272）。
结果
（1）rs1800775、rs3764261、rs12149545、rs711752和rs708272的基因型和等位基因频率分布在对照组和MS组之间存在显著差异（均P<0.05）。（2）rs1800775、rs3764261、rs12149545、rs711752和rs708272多态性与MS风险显著相关（均P<0.05）。（3）rs1800775多态性与空腹血糖水平升高和高密度脂蛋白胆固醇（HDL-C）降低有关；rs3764261和rs12149545多态性与除高血压外的MS所有组分有关；rs711752和rs708272多态性与HDL-C降低有关（均P<0.05）。（4）发现两对单核苷酸多态性（SNP）存在完全连锁不平衡（LD）（rs3764261和rs12149545（D'=1.000，r²=0.931），rs711752和rs708272（D'=1.000，r²=0.996））。（5）A-G-G-G-C（P=0.013，比值比[OR]=0.622，95%置信区间[95%CI]=0.427-0.906）和A-T-A-A-T（P<0.001，OR=0.519，95%CI=0.386-0.697）单倍型在对照组中比病例组中更常见。结论：在维吾尔族人群中，基因的rs1800775、rs3764261、rs12149545、rs711752和rs708272多态性与MS及其组分有关。在两对SNP（rs3764261和rs12149545、rs711752和rs708272）之间发现完全LD。A-G-G-G-C和A-T-A-A-T单倍型可能是MS的保护因素。
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