Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
BMC Endocr Disord. 2023 Jul 5;23(1):138. doi: 10.1186/s12902-023-01391-6.
Gene-diet interaction plays a key role in the inter-individual differences in lipid abnormalities as a major risk factor for cardiovascular diseases (CVDs). Thus, we explored the interaction between CETP TaqB1 polymorphism with dietary acid load (DAL) on lipid profile among type 2 diabetes mellitus (T2DM).
This cross-sectional study conducted on 220 Iranian patients with T2DM. Dietary acid load (PRAL and NEAP) was calculated via a validated food-frequency questionnaire (FFQ). The polymerase chain reaction (PCR) used for genotyping Taq1B polymorphism. Biochemical markers were measured by standard protocol. The interaction between CETP Taq1B polymorphism and DAL (PRAL and NEAP) on lipid profile was performed by a generalized linear regression model (GLM).
The overall prevalence of rs708272 genotypes was 8.6%, 72.7% and 18.6% for B1B1, B1B2 and B2B2 genotype respectively. This study showed that people with the B1B1 genotype had greater LDL, TC, LDL/HDL, and TG when they consumed diets that scored higher on the NEAP and PRAL indexes than those with the B1B2 and B2B2 genotypes. Besides, carriers of the B1B1 allele who were in the highest tertile of NEAP, had lower HDL (P Interaction < 0.05).
In summary, the lipid profile might be improved in B1B1 homozygotes by less adherence to DAL indexes, however, the findings should be validated in high-quality interventional studies.
基因-饮食相互作用在脂质异常作为心血管疾病（CVDs）主要危险因素的个体差异中起着关键作用。因此，我们探讨了CETP TaqB1 多态性与饮食酸负荷（DAL）在 2 型糖尿病（T2DM）患者脂质谱中的相互作用。
本横断面研究纳入了 220 例伊朗 2 型糖尿病患者。通过验证后的食物频率问卷（FFQ）计算饮食酸负荷（PRAL 和 NEAP）。采用聚合酶链反应（PCR）检测 Taq1B 多态性。采用标准方案测量生化标志物。采用广义线性回归模型（GLM）研究 CETP Taq1B 多态性与 DAL（PRAL 和 NEAP）对脂质谱的相互作用。
rs708272 基因型的总体发生率分别为 B1B1、B1B2 和 B2B2 基因型 8.6%、72.7%和 18.6%。本研究表明，与 B1B2 和 B2B2 基因型相比，当 NEAP 和 PRAL 指数较高时，B1B1 基因型的个体 LDL、TC、LDL/HDL 和 TG 较高。此外，NEAP 最高三分位的 B1B1 等位基因携带者 HDL 较低（P 交互<0.05）。
总之，B1B1 纯合子通过较少地遵循 DAL 指数，可能会改善血脂谱，但这些发现应在高质量的干预性研究中得到验证。
