阿福唑及其主要代谢产物在大鼠体内的组织分布情况。
Tissue availability of afobazole and its major metabolites in rats.
作者信息
Viglinskaya A O, Kolyvanov G B, Litvin A A, Kravtsova O Yu, Zherdev V P, Seredenin S B
机构信息
Laboratory of Pharmacokinetics, V V Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2007 May;143(5):593-4. doi: 10.1007/s10517-007-0189-5.
Intraperitoneally injected afobazole and its major metabolites are intensively distributed in highly vascularized tissues of rats, including the liver, spleen, and kidneys; the content of these compounds in moderately and poorly vascularized tissues (muscles and mesentery) is much lower. Afobazole and its metabolites possess intermediate ability to penetrate into the brain.
腹腔注射的阿福唑及其主要代谢产物在大鼠的高血管化组织中大量分布，包括肝脏、脾脏和肾脏；这些化合物在血管化程度中等和较差的组织（肌肉和肠系膜）中的含量要低得多。阿福唑及其代谢产物具有中等程度的穿透大脑的能力。
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