[Model study of afobazole distribution in pregnant and lactating female rats and infant rat pups].
作者信息
Shreder O V, Kolyvanov G B, Litvin A A, Bastrygin D V, Shreder E D, Solomina A S, Viglinskaia A O, Zabrodina V V, Zherdev V P, Durnev A D, Seredenin S B
出版信息
Eksp Klin Farmakol. 2010 Aug;73(8):17-20.
PMID:20919552
Abstract
Afobazole and M-11, its major metabolite were detected in placental and embryonic rat tissues after single peroral administration to pregnant female rats at a dose of 100 mg/kg. The anxiolytic drug and its metabolite are also detected in rat milk and body of the breast-fed infant rat pups after 4 days of daily administration (200 mg/kg, per os) to lactating female rats.
摘要
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