Umarova B A, Kopylova G N, Smirnova E A, Guseva A A, Zhuikova S E
Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University.
Bull Exp Biol Med. 2003 Oct;136(4):325-7. doi: 10.1023/b:bebm.0000010942.14275.50.
Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.
应激增加了大鼠肠系膜和皮下脂肪中肥大细胞的分泌活性。在应激前1小时分别腹腔注射剂量为0.05和1mg/kg的Semax和脯氨酰 - 甘氨酰 - 脯氨酸可消除这种作用。受试制剂对未应激动物肥大细胞的分泌活性没有调节作用。Semax和脯氨酰 - 甘氨酰 - 脯氨酸在体外可防止促皮质素和乙酰胆碱激活肥大细胞。肽对肥大细胞的稳定作用可能决定了它们的抗溃疡活性。
