肾上腺素增强了氟哌啶醇对大鼠的抗精神病作用，但未增强其致僵作用。

Epinephrine potentiates antipsychotic, but not cataleptogenic effect of haloperidol in rats.

作者信息

Gmiro V E, Serdyuk S E

机构信息

Institute of Experimental Medicine, Russian Academy of Medical Sciences, St Petersburg, Russia.

出版信息

Bull Exp Biol Med. 2007 May;143(5):617-9. doi: 10.1007/s10517-007-0197-5.

DOI:10.1007/s10517-007-0197-5

PMID:18239784

Abstract

Intramuscular injection of haloperidol or epinephrine in a minimum effective dose produces the maximum antipsychotic effect in rat model of schizophrenia, i.e. completely removes stereotypy, hyperlocomotion, and ataxia induced by MK-801. Haloperidol in the specified dose induces catalepsy, while epinephrine exhibits no cataleptogenic effect. Combined intramuscular injection of haloperidol and epinephrine in the threshold doses, ineffective in monotherapy, causes the maximum antipsychotic effect, but not catalepsy. Preliminary anesthesia of the gastric mucosa with 1% lidocaine and blockade of intramural ganglia in the gastric mucosa with hexamethonium completely abolished the potentiated antipsychotic effects produced by combined treatment with haloperidol and epinephrine. Hence, potentiation of the antipsychotic effect of haloperidol with epinephrine is related to stimulation of afferents in the gastric mucosa.

摘要

在精神分裂症大鼠模型中，肌肉注射最小有效剂量的氟哌啶醇或肾上腺素可产生最大抗精神病作用，即完全消除由MK - 801诱导的刻板行为、运动亢进和共济失调。特定剂量的氟哌啶醇可诱发僵住症，而肾上腺素无致僵住症作用。肌肉注射阈剂量的氟哌啶醇和肾上腺素，单用时无效，但联合使用可产生最大抗精神病作用，且不诱发僵住症。用1%利多卡因对胃黏膜进行预处理麻醉，并用六甲铵阻断胃黏膜壁内神经节，可完全消除氟哌啶醇和肾上腺素联合治疗所产生的增强抗精神病作用。因此，肾上腺素增强氟哌啶醇的抗精神病作用与刺激胃黏膜传入神经有关。