[锂对大鼠各种抗精神病药物致僵特性的影响]
[Lithium modifications of the cataleptogenic properties of various neuroleptic drugs in the rat].
作者信息
Dessaigne S, Scotto A M, Guigues M
出版信息
C R Seances Soc Biol Fil. 1978;172(6):1173-80.
After unique ip injection (11,78 mEq/kg) LiCl increases in the Rat catalepsy produced by chlorpromazine, prochlorperazine, fluphenazine, levomepromazine, haloperidol and reserpine. This phenomenon is more important according to cataleptigenic properties of neuroleptic drugs. After repeated injections of LiCl (5 mEq/kg/d/5 dip) potentiation of catalepsy is more fugacious and not produced by levomepromazine and reserpine. LiCl would interfere at enzymatic level with dopaminergic transmission either by inhibiting activity of cerebral adenylcyclase (unique injection) or by inhibiting dopamine synthesis (repeated injections).
单次腹腔注射氯化锂（11.78 毫当量/千克）后，可增强氯丙嗪、丙氯拉嗪、氟奋乃静、左美丙嗪、氟哌啶醇和利血平所致大鼠的僵住症。根据抗精神病药物的致僵住症特性，这一现象更为显著。多次注射氯化锂（5 毫当量/千克/天，共 5 次）后，僵住症的增强作用更为短暂，且左美丙嗪和利血平不会引发此现象。氯化锂可能通过抑制脑腺苷酸环化酶的活性（单次注射）或抑制多巴胺合成（多次注射），在酶水平上干扰多巴胺能传递。
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