Naslednikova I O, Konenkov V I, Ryazantseva N V, Novitskii V V, Tkachenko S B, Zima A P, Avdoshina V V, Beloborodova E I, Beloborodova E V, Dortman V V
Department of Pathophysiology, Siberian State Medical University, Federal Agency of Health Care and Social Development, Tomsk.
Bull Exp Biol Med. 2007 Jun;143(6):706-12. doi: 10.1007/s10517-007-0220-x.
Immunopathogenesis of chronic viral hepatitides was studied by modern immunological, molecular, genetic methods. We revealed an imbalance in the production of immunoregulatory cytokines by mononuclear leukocytes (primarily of the Th2 type). The risk of progression and chronic course of viral hepatitides in Caucasian population was associated with alleles of promoter regions -330G and -592A in the IL-2 and IL-10 genes, respectively, as well as with the T/T genotype of the polymorphic region C590T in the IL-4 gene. The C/C genotype of the IL-10 gene promoter region C592A was shown to be a factor determining resistance to long-term persistence of hepatitis B and C viruses.
采用现代免疫学、分子学和遗传学方法研究了慢性病毒性肝炎的免疫发病机制。我们发现单核白细胞（主要是Th2型）产生免疫调节细胞因子失衡。白种人群中病毒性肝炎进展和慢性病程的风险分别与IL-2基因启动子区域-330G和IL-10基因启动子区域-592A的等位基因以及IL-4基因多态性区域C590T的T/T基因型有关。IL-10基因启动子区域C592A的C/C基因型被证明是决定对乙型和丙型肝炎病毒长期持续感染具有抗性的一个因素。
