Bruno Cosimo Marcello, Valenti Maria, Bertino Gaetano, Ardiri Annalisa, Amoroso Alfredo, Consolo Maria, Mazzarino Clorinda Maria, Neri Sergio
Department of Internal Medicine and Systemic Diseases, University of Catania, Catania, Italy.
Ann Saudi Med. 2011 Jul-Aug;31(4):360-4. doi: 10.4103/0256-4947.83215.
An imbalance in cytokine production may be involved in the pathogenesis of chronic C hepatitis. The aim of the study was to investigate circulating levels of interleukin-10 (IL-10) in a selected cohort of patients affected by chronic C hepatitis.
Retrospective study based on consecutive hepatitis C virus patients, affected by chronic active hepatitis, attending the general hospital of hepatology unit from June to September 2009
A total of 49 patients with chronic C hepatitis and 20 healthy control subjects similar in gender and age were examined. Circulating IL-10 was assessed by ELISA commercial kit (R and D Systems) in all investigated subjects.
There was no significant difference in IL-10 values between controls and overall patients (P>.05). Nevertheless, among patients, subjects with more severe necroinflammation had higher values than others (P<.001). Moreover, a close relationship was found between IL-10 values and serum aspartate aminotransferase (r=0.61; P<.001).
These findings suggest that IL-10 may be a useful additional marker to assess necroinflammation and to monitor the evolution of liver damage. They also argue for a potential pathophysiological role for IL-10 in the persistence and progression of hepatitis.
细胞因子产生失衡可能参与慢性丙型肝炎的发病机制。本研究旨在调查一组慢性丙型肝炎患者中白细胞介素-10（IL-10）的循环水平。
基于2009年6月至9月在综合医院肝病科就诊的连续丙型肝炎病毒感染的慢性活动性肝炎患者进行的回顾性研究。
共检查了49例慢性丙型肝炎患者和20名年龄和性别匹配的健康对照者。采用ELISA商业试剂盒（R和D系统）对所有研究对象的循环IL-10进行评估。
对照组与所有患者的IL-10值无显著差异（P>0.05）。然而，在患者中，坏死性炎症更严重的患者的IL-10值高于其他患者（P<0.001）。此外，IL-10值与血清天冬氨酸转氨酶之间存在密切关系（r=0.61；P<0.001）。
这些发现表明，IL-10可能是评估坏死性炎症和监测肝损伤进展的有用附加标志物。它们还支持IL-10在肝炎持续和进展中的潜在病理生理作用。
