蛋白激酶A激活剂8-溴环磷腺苷在强迫游泳试验中的抗抑郁样活性。
Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test.
作者信息
Brański Piotr, Palucha Agnieszka, Szewczyk Bernadeta, Wierońska Joanna M, Pilc Andrzej, Nowak Gabriel
机构信息
Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
出版信息
J Neural Transm (Vienna). 2008 Jun;115(6):829-30. doi: 10.1007/s00702-008-0023-x. Epub 2008 Feb 1.
PMID:18239846
Abstract
The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.
摘要
蛋白激酶A（PKA）激活剂8-溴环磷酸腺苷（8-Br-cAMP）能剂量依赖性地减少大鼠强迫游泳试验中的不动时间。这种作用可被与选择性PKA抑制剂Rp-环磷酸腺苷（Rp-cAMPS）共同处理所拮抗。这是首次证明PKA激活剂具有类抗抑郁活性。
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