幽门螺杆菌根除：一项关于含或不含依卡倍特钠三联疗法的随机前瞻性研究。
H pylori eradication: a randomized prospective study of triple therapy with or without ecabet sodium.
作者信息
Kim Hyung Wook, Kim Gwang Ha, Cheong Jong Yun, Yang Ung Suk, Park Seung Keun, Song Chul Soo, Kang Dae Hwan, Song Geun Am
机构信息
Department of Internal Medicine, Bongseng Memorial Hospital, Busan, Korea.
出版信息
World J Gastroenterol. 2008 Feb 14;14(6):908-12. doi: 10.3748/wjg.14.908.
AIM
To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate.
METHODS
Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative (13)C-urea breath test 6-8 wk after completion of treatment.
RESULTS
After completion of therapy, 194/257 patients showed negative (13)C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups.
CONCLUSION
Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori.
目的
研究在幽门螺杆菌感染的标准三联疗法中添加埃索美拉唑钠是否能提高根除率。
方法
257例幽门螺杆菌感染患者被随机分为标准三联疗法组（A组，n = 129）或三联疗法加埃索美拉唑钠组（B组，n = 128）。成功根除定义为治疗结束后6 - 8周（13）C - 尿素呼气试验阴性。
结果
治疗结束后，257例患者中有194例（13）C - 尿素呼气试验结果为阴性。根据意向性分析，A组129例患者中有93例（72.1%）感染被根除，B组128例患者中有101例（78.9%）感染被根除（P = 0.204）。符合方案分析显示，A组118例患者中有93例（78.8%）成功根除，B组114例患者中有101例（88.6%）成功根除（P = 0.044）。两个治疗组患者经历的副作用无显著差异。
结论
我们的结果表明，添加埃索美拉唑钠可提高幽门螺杆菌标准三联疗法的疗效。
Zotero 插件