• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[一种ATP类似物，腺苷5'-磷酸氢磷酸在己糖激酶和果糖-6-磷酸激酶催化反应中的作用]

[Action of an ATP analog, adenosine 5'-hyophosphophosphate in the reactions catalysed by hexokinase and fructose-6-phosphate kinase].

作者信息

Setondi J, Remy P, Dirheimer G

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 May 17;282(19):1757-60.

PMID:182408
Abstract

Adenosine 5'-hypoposphate phosphorylates glucose and fructose 6-phosphate in the presence of hexokinase and fructose 6-phosphate kinase respectively. It behaves as a competitive inhibitor versus ATP in the hexokinase reaction. Its affinity for the two enzymes is similar to that of ATP, the maximal velocities being however much lower.

摘要

5'-次磷酸腺苷在己糖激酶和6-磷酸果糖激酶存在的情况下，分别使葡萄糖和6-磷酸果糖磷酸化。在己糖激酶反应中，它作为ATP的竞争性抑制剂。它对这两种酶的亲和力与ATP相似，然而最大反应速度要低得多。

相似文献

1
[Action of an ATP analog, adenosine 5'-hyophosphophosphate in the reactions catalysed by hexokinase and fructose-6-phosphate kinase].[一种ATP类似物，腺苷5'-磷酸氢磷酸在己糖激酶和果糖-6-磷酸激酶催化反应中的作用]
C R Acad Hebd Seances Acad Sci D. 1976 May 17;282(19):1757-60.
2
Design of substrate-site-directed inhibitors of adenylate kinase and hexokinase. Effect of substrate substituents on affinity on affinity for the adenine nucleotide sites.
J Med Chem. 1976 Dec;19(12):1371-7. doi: 10.1021/jm00234a004.
3
Inhibition of hexokinase by multisubstrate analogs.
Biochim Biophys Acta. 1977 Feb 9;480(2):351-6. doi: 10.1016/0005-2744(77)90027-4.
4
Sensitivity of yeast glycolytic enzymes to chloroquine.酵母糖酵解酶对氯喹的敏感性。
Arch Microbiol. 1988;150(3):309-12. doi: 10.1007/BF00407797.
5
Regulation of human erythrocyte hexokinase. The influence of glycolytic intermediates and inorganic phosphate.人红细胞己糖激酶的调节。糖酵解中间产物和无机磷酸盐的影响。
Biochim Biophys Acta. 1977 Nov 23;485(1):75-86. doi: 10.1016/0005-2744(77)90194-2.
6
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 3. Synthesis of adenosine 5'-triphosphate derivatives with N6- or 8-substituents bearing iodoacetyl groups.
J Med Chem. 1982 Apr;25(4):373-81. doi: 10.1021/jm00346a009.
7
Inactivation of brain hexokinase by an adenosine 5'-triphosphate analog.一种腺苷5'-三磷酸类似物对脑己糖激酶的失活作用。
Arch Biochem Biophys. 1977 May;181(1):19-25. doi: 10.1016/0003-9861(77)90478-7.
8
Inactivation of rabbit, pig, and carp adenylate kinases by N6-o- and p-fluorobenzoyladenosine 5'-triphosphates.
Biochemistry. 1975 Dec 16;14(25):5438-44. doi: 10.1021/bi00696a009.
9
Inhibition of T4 polynucleotide kinase by the ATP analog, beta, gamma-imidoadenylyl 5'-triphosphate.
Biochim Biophys Acta. 1978 Aug 7;525(2):357-63. doi: 10.1016/0005-2744(78)90230-9.
10
Inhibition of brain hexokinase by a multisubstrate analog results from binding to a discrete regulatory site.多底物类似物对脑己糖激酶的抑制作用源于其与一个离散调控位点的结合。
Biochem Biophys Res Commun. 1984 Jan 13;118(1):90-6. doi: 10.1016/0006-291x(84)91071-4.