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[一种ATP类似物,腺苷5'-磷酸氢磷酸在己糖激酶和果糖-6-磷酸激酶催化反应中的作用]

[Action of an ATP analog, adenosine 5'-hyophosphophosphate in the reactions catalysed by hexokinase and fructose-6-phosphate kinase].

作者信息

Setondi J, Remy P, Dirheimer G

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 May 17;282(19):1757-60.

PMID:182408
Abstract

Adenosine 5'-hypoposphate phosphorylates glucose and fructose 6-phosphate in the presence of hexokinase and fructose 6-phosphate kinase respectively. It behaves as a competitive inhibitor versus ATP in the hexokinase reaction. Its affinity for the two enzymes is similar to that of ATP, the maximal velocities being however much lower.

摘要

5'-次磷酸腺苷在己糖激酶和6-磷酸果糖激酶存在的情况下,分别使葡萄糖和6-磷酸果糖磷酸化。在己糖激酶反应中,它作为ATP的竞争性抑制剂。它对这两种酶的亲和力与ATP相似,然而最大反应速度要低得多。

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