Lei Cheng-Zhi, Xiang Yang, Ao Guo-Kun, Li Li, Shi Ying-Chang, Bao Yi-Rong, Xu Cong-Jian, Hong Hong, Lang Jing-He
Department of Gynecological Oncology, Cancer Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Zhonghua Fu Chan Ke Za Zhi. 2007 Oct;42(10):701-4.
To investigate the impact of danazol alginate microspheres used for uterine arterial embolization (UAE) on ovarian function and subsequent pregnancy using rabbit as a model.
A total of 32 female rabbits were divided into 3 groups: a control group, danazol alginate microspheres (DKMG) group and alginate microspheres (KMG) group. Basal serum estradiol (E(2)), follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T) levels before UAE and 1 - 3 months after UAE were compared for all rabbits. In breeding field all rabbits mated after UAE. Estrus, and pregnancy rate were observed by veterinary.
There were no significant changes from baseline FSH, LH, E(2), T levels measured at 1, 2 and 3 months after UAE (P > 0.05). The total pregnancy rate of DKMG or KMG group was 0 within 2 - 4 months after UAE. Compared to the control group (4/8), the difference was statistically significant (P < 0.05); the total pregnancy rate of DKMG, KMG and control groups within 5 - 7 months after UAE, respectively 17% (2/12), 25% (3/12) and 5/8 (P > 0.05); the total pregnancy rate was 42% (5/12), 50% (6/12) and 6/8 respectively within 8 - 10 months after UAE, there were also no significant differences between the three groups (P > 0.05).
There is no obvious effect of danazol alginate microspheres used for uterine arterial embolization on ovarian function in rabbits. After UAE some animals are able to achieve pregnancies, while harmful effects are observed on short term pregnant rate.
以兔为模型，研究用于子宫动脉栓塞术（UAE）的达那唑海藻酸钠微球对卵巢功能及后续妊娠的影响。
将32只雌性兔分为3组：对照组、达那唑海藻酸钠微球（DKMG）组和海藻酸钠微球（KMG）组。比较所有兔在UAE术前及术后1 - 3个月的基础血清雌二醇（E₂）、卵泡刺激素（FSH）、黄体生成素（LH）、睾酮（T）水平。在繁殖期，所有兔在UAE术后进行交配。由兽医观察发情情况及妊娠率。
UAE术后1、2和3个月时，FSH、LH、E₂、T水平与基线相比无显著变化（P > 0.05）。DKMG组或KMG组在UAE术后2 - 4个月内总妊娠率为0。与对照组（4/8）相比，差异有统计学意义（P < 0.05）；DKMG组、KMG组和对照组在UAE术后5 - 7个月内的总妊娠率分别为17%（2/12）、25%（3/12）和5/8（P > 0.05）；UAE术后8 - 10个月内总妊娠率分别为42%（5/12）、50%（6/12）和6/8，三组间也无显著差异（P > 0.05）。
用于子宫动脉栓塞的达那唑海藻酸钠微球对兔卵巢功能无明显影响。UAE术后部分动物能够妊娠，但短期内对妊娠率有不良影响。
