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在公共卫生风险评估中使用蒙特卡罗模拟:估计并呈现风险的完整分布

Using Monte Carlo simulations in public health risk assessments: estimating and presenting full distributions of risk.

作者信息

Burmaster D E, von Stackelberg K

机构信息

Alceon Corporation, Cambridge, MA 02238-2669.

出版信息

J Expo Anal Environ Epidemiol. 1991 Oct;1(4):491-512.

PMID:1824330
Abstract

With desktop computers as powerful as mainframes were just a few years ago, analysts can now use commercial software to estimate full probability distributions for--not just point estimates of--health risks experienced by people chronically exposed to toxic chemicals at or near hazardous waste sites. Even though probability is the central concept in risk assessment, and even though probabilistic methods offer strong advantages and insights as compared to the "deterministic" methods now required by U.S. Environmental Protection Agency's guidance manuals, analysts have only begun to use probabilistic methods at Superfund sites. In this paper, we examine a simplified case study using Monte Carlo methods to estimate full distributions of public health risk. We demonstrate the use of "toggles" to isolate the contributions of different inputs, and we also offer new graphical methods to communicate the results to risk managers and concerned citizens.

摘要

如今的台式计算机已拥有几年前大型主机那样强大的功能,分析人员现在可以使用商业软件来估计长期接触危险废物场地或其附近有毒化学品的人群所面临的健康风险的完整概率分布,而不仅仅是点估计。尽管概率是风险评估的核心概念,而且与美国环境保护局指导手册目前要求的“确定性”方法相比,概率方法具有强大的优势和深刻见解,但分析人员在超级基金场地才刚刚开始使用概率方法。在本文中,我们研究了一个简化的案例研究,使用蒙特卡罗方法来估计公共健康风险的完整分布。我们展示了如何使用“切换”来分离不同输入的贡献,并且我们还提供了新的图形方法,以便将结果传达给风险管理者和相关民众。

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