Spear Gregory T, Zariffard M Reza, Cohen Mardge H, Sha Beverly E
Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL 60612, USA.
J Reprod Immunol. 2008 Jun;78(1):76-9. doi: 10.1016/j.jri.2007.11.001. Epub 2008 Feb 19.
IL-8/CXCL8 is induced during infections, but has not been reported for Candida albicans colonization of the female genital tract. Cervicovaginal lavage (CVL) samples were collected from 406 HIV-infected women. IL-8 levels were evaluated by ELISA and compared with levels of C. albicans detected by potassium hydroxide (KOH) and PCR. Levels of lactobacilli, Gardnerella vaginalis and Mycoplasma hominis were also determined by PCR. IL-8 was significantly higher in samples from women with Candida, and regression analysis showed a positive association between IL-8 and Candida. In contrast, there was an inverse relationship between lactobacilli and IL-8. G. vaginalis and M. hominis were not significantly associated with IL-8. This study has shown an association between C. albicans and levels of IL-8 in mucosal genital fluid.
白细胞介素-8/趋化因子配体8（IL-8/CXCL8）在感染过程中会被诱导产生，但白色念珠菌在女性生殖道定植时该因子的情况尚无报道。从406名感染艾滋病毒的女性中采集了宫颈阴道灌洗（CVL）样本。通过酶联免疫吸附测定（ELISA）评估IL-8水平，并与通过氢氧化钾（KOH）和聚合酶链反应（PCR）检测到的白色念珠菌水平进行比较。还通过PCR测定了乳酸杆菌、阴道加德纳菌和人型支原体的水平。念珠菌感染女性的样本中IL-8水平显著更高，回归分析显示IL-8与念珠菌之间呈正相关。相比之下，乳酸杆菌与IL-8呈负相关。阴道加德纳菌和人型支原体与IL-8无显著关联。本研究表明白色念珠菌与黏膜生殖道液中IL-8水平之间存在关联。
