Histopathological studies in relation to protection induced by using MDP as an adjuvant in malaria.

Different immunomodulators were tried for their efficacy to protect against the lethal infection of Plasmodium berghei in mice. Since MDP was the most effective non-FCA adjuvant imparting a significant degree of protection, histopathological studies were undertaken in mice protected by using this adjuvant in comparison with mice suffering from acute malaria. The malarious mice revealed abnormalities of the liver, spleen and kidney, whereas these abnormalities were minimal in the MDP-immunized mice. The results are consistent with the degree of protection induced by MDP, and are significant with respect to the effectiveness of the non-FCA adjuvant in causing minimal histopathological abnormalities.