Khullar N, Sehgal S
Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Exp Biol. 1990 Dec;28(12):1112-7.
Different adjuvants were assessed for their role in conferring protection against the rodent malarial parasite P. berghei and compared with the classical Freund's complete adjuvant (FCA). Pretreatment of mice with trehalose dimycolate (TDM) mixed with antigen (Ag), sulpholipids (SL) mixed with Ag, muramyl dipeptide (MDP) alone, liposomes containing Ag and phosphomannoinositides (PIM) mixed with Ag were ineffective in conferring protection. However, MDP given with squalane (Sq) and Ag, MDP with incomplete Freund's adjuvant (IFA) and Ag, palmitoyl-MDP with Sq and Ag, aluminium hydroxide adsorbed Ag, and FCA with Ag were effective in conferring varying degrees of protection to mice. Complete protection in rats was obtained with MDP mixed with Sq and Ag, and FCA mixed with Ag, and a partial protection with liposomes containing Ag.
评估了不同佐剂在赋予小鼠抗啮齿动物疟原虫伯氏疟原虫保护作用中的角色，并与经典的弗氏完全佐剂（FCA）进行比较。用与抗原（Ag）混合的海藻糖二霉菌酸酯（TDM）、与Ag混合的硫脂（SL）、单独的胞壁酰二肽（MDP）、含Ag的脂质体以及与Ag混合的磷酸甘露糖脂（PIM）对小鼠进行预处理，均无法赋予保护作用。然而，与角鲨烷（Sq）和Ag一起给予的MDP、与不完全弗氏佐剂（IFA）和Ag一起的MDP、与Sq和Ag一起的棕榈酰-MDP、氢氧化铝吸附的Ag以及与Ag一起的FCA，均能有效地给予小鼠不同程度的保护。用与Sq和Ag混合的MDP以及与Ag混合的FCA可使大鼠获得完全保护，含Ag的脂质体可使大鼠获得部分保护。
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