Pailhoux E, Martinez A, Veyssière G, Tournaire C, Berger M, Jean C
Laboratoire de Physiologie Comparée et Endocrinologie, URA-CNRS 360, Les Cézeaux, Aubière.
Ann Endocrinol (Paris). 1991;52(6):437-40.
A 34.5 kDa abundant protein named MVDP (Mouse Vas Deferens Protein) is produced and secreted by vas deferens epithelial cells from adult mice. Steady-state levels of MVDP and its 1.4 kb mRNA are markedly decreased 30 days after castration. Testosterone treatment for 2 weeks is necessary to completely reverse the effect of castration. A cDNA encoding MVDP has been cloned and entirely sequenced. A protein of 316 amino acids encoded by an open reading frame of 948 nucleotides shows 82% homology with a human placental aldose reductase. A gene corresponding to MVDP cDNA has been recently isolated ans characterized. The gene extends over approximately 11 kb and consists of 10 exons. Its structure is very similar to that of the human aldose reductase gene. The promotor region of MVDP gene contains an androgen responsive element consensus located 97 nucleotides upstream the transcription initiation site.
一种名为MVDP（小鼠输精管蛋白）的34.5 kDa丰富蛋白由成年小鼠的输精管上皮细胞产生并分泌。去势30天后，MVDP及其1.4 kb mRNA的稳态水平显著降低。需要进行2周的睾酮治疗才能完全逆转去势的影响。编码MVDP的cDNA已被克隆并完全测序。由948个核苷酸的开放阅读框编码的316个氨基酸的蛋白质与人类胎盘醛糖还原酶具有82%的同源性。最近已分离并鉴定了与MVDP cDNA对应的基因。该基因长度约为11 kb，由10个外显子组成。其结构与人类醛糖还原酶基因非常相似。MVDP基因的启动子区域在转录起始位点上游97个核苷酸处含有一个雄激素反应元件共有序列。
