Pomarol-Clotet E, Oh T M S S, Laws K R, McKenna P J
Br J Psychiatry. 2008 Feb;192(2):92-7. doi: 10.1192/bjp.bp.106.032102.
Increased semantic priming is an influential theory of thought disorder in schizophrenia. However, studies to date have had conflicting findings.
To investigate semantic memory in patients with schizophrenia with and without thought disorder.
Data were pooled from 36 studies comparing patients with schizophrenia and normal controls in semantic priming tasks. Data from 18 studies comparing patients with thought disorder with normal controls, and 13 studies comparing patients with and without thought disorder were also pooled.
There was no support for altered semantic priming in schizophrenia as a whole. Increased semantic priming in patients with thought disorder was supported, but this was significant only in comparison with normal controls and not in comparison with patients without thought disorder. Stimulus onset asynchrony (SOA) and general slowing of reaction time moderated the effect size for priming in patients with thought disorder.
Meta-analysis provides qualified support for increased semantic priming as a psychological abnormality underlying thought disorder. However, the possibility that the effect is an artefact of general slowing of reaction time in schizophrenia has not been excluded.
语义启动增强是精神分裂症思维障碍的一种有影响力的理论。然而，迄今为止的研究结果相互矛盾。
研究有和没有思维障碍的精神分裂症患者的语义记忆。
汇总了36项在语义启动任务中比较精神分裂症患者与正常对照的研究数据。还汇总了18项比较有思维障碍患者与正常对照的研究数据，以及13项比较有和没有思维障碍患者的研究数据。
总体上不支持精神分裂症患者语义启动改变。支持有思维障碍患者语义启动增强，但这仅在与正常对照比较时显著，与没有思维障碍的患者比较时不显著。刺激开始异步性（SOA）和反应时间的总体减慢调节了有思维障碍患者启动的效应大小。
荟萃分析为语义启动增强作为思维障碍潜在的心理异常提供了有限的支持。然而，尚未排除该效应是精神分裂症反应时间总体减慢的人为结果的可能性。
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