Vidt D G, Borazanian R A
Department of Hypertension and Nephrology, Cleveland Clinic Foundation.
Geriatrics. 1991 Jan;46(1):28-30, 33-4, 36-8.
Though the calcium channel blockers have been used to treat angina pectoris for almost a decade, the long-acting forms of these agents that have become available in the last few years have made them practical for use as antihypertensive agents as well. They are becoming increasingly popular in this role, especially to treat elderly hypertensive patients. Because they are vasodilators with a mild diuretic action, they are logical treatment choices for the majority of hypertensive patients who have increased peripheral vascular resistance. They offer the advantage of a dual benefit for hypertensive patients with angina, and they have no effect on carbohydrate or lipid metabolism. Disadvantages include cost and a side effect profile that includes headaches, palpitations, ankle edema, and constipation.
尽管钙通道阻滞剂用于治疗心绞痛已近十年，但过去几年中出现的长效制剂使它们也适用于抗高血压治疗。它们在这一作用中越来越受欢迎，尤其适用于治疗老年高血压患者。由于它们是具有轻度利尿作用的血管扩张剂，对于大多数外周血管阻力增加的高血压患者来说，是合理的治疗选择。它们为合并心绞痛的高血压患者带来双重获益，且对碳水化合物或脂质代谢无影响。缺点包括成本以及副作用，如头痛、心悸、踝部水肿和便秘。
