Miller J M, Bredberg G, Grenman R, Suonpää J, Lindström B, Didier A
Kresge Hearing Research Institute, University of Michigan, Ann Arbor 48109-0506.
Ann Otol Rhinol Laryngol. 1991 Jan;100(1):44-53. doi: 10.1177/000348949110000108.
Cochlear blood flow (CBF) was measured with a laser-Doppler (L-D) flowmeter (Periflux PR2-B) in four unanesthetized human subjects with chronic tympanic membrane perforations and nine anesthetized human subjects undergoing middle ear operations. The L-D recordings were made over the promontory and/or the round window membrane during carbogen breathing and direct electrical stimulation of the cochlea in both groups and with warm water irrigation of the external ear canal in the anesthetized subjects. Carbogen led to little or no change in CBF as monitored with either measurement approach in either subject group. Electrical stimulation yielded an increase (15% to 25%) in CBF as recorded from the promontory in seven of the nine subjects tested. Warm (44 degrees C to 49 degrees C) water irrigation produced changes of 20% to 60% in CBF that were partially recoverable in the 10 minutes available for study. This study demonstrated the feasibility of direct CBF measurement in humans with the L-D method. Moreover, the data indicate that carbogen has little influence on CBF and that electrical stimulation at relatively safe levels and warm water irrigation of the ear canal produce increases in human CBF.
使用激光多普勒（L-D）流量计（Periflux PR2-B），对4名患有慢性鼓膜穿孔的未麻醉人类受试者以及9名接受中耳手术的麻醉人类受试者测量了耳蜗血流量（CBF）。在两组受试者进行二氧化碳混合气呼吸和耳蜗直接电刺激期间，以及在麻醉受试者中用温水冲洗外耳道时，在岬部和/或圆窗膜上进行L-D记录。在任一受试者组中，无论采用哪种测量方法，二氧化碳混合气对监测到的CBF几乎没有影响或没有影响。在9名接受测试的受试者中，有7名受试者的岬部记录显示，电刺激使CBF增加了15%至25%。温暖（44摄氏度至49摄氏度）水冲洗使CBF产生了20%至60%的变化，在可供研究的10分钟内部分可恢复。本研究证明了用L-D方法直接测量人类CBF的可行性。此外，数据表明，二氧化碳混合气对CBF影响很小，相对安全水平的电刺激和外耳道温水冲洗会使人类CBF增加。
