Schreiber Sharon, Savla Mayur, Pelekhov Denis V, Iscru Daniel F, Selcu Camelia, Hammel P Chris, Agarwal Gunjan
Biomedical Engineering Department, Ohio State University, 270 Bevis Hall, 1080 Carmack Road, Columbus, OH 43210, USA.
Small. 2008 Feb;4(2):270-8. doi: 10.1002/smll.200700116.
The use of magnetic force microscopy (MFM) to detect probe-sample interactions from superparamagnetic nanoparticles in vitro in ambient atmospheric conditions is reported here. By using both magnetic and nonmagnetic probes in dynamic lift-mode imaging and by controlling the direction and magnitude of the external magnetic field applied to the samples, it is possible to detect and identify the presence of superparamagnetic nanoparticles. The experimental results shown here are in agreement with the estimated sensitivity of the MFM technique. The potential and challenges for localizing nanoscale magnetic domains in biological samples is discussed.
本文报道了在环境大气条件下利用磁力显微镜（MFM）在体外检测超顺磁性纳米颗粒与探针-样品之间的相互作用。通过在动态提升模式成像中使用磁性和非磁性探针，并控制施加到样品上的外部磁场的方向和大小，可以检测和识别超顺磁性纳米颗粒的存在。此处所示的实验结果与MFM技术的估计灵敏度一致。讨论了在生物样品中定位纳米级磁畴的潜力和挑战。
