银催化叔卤代烃和仲卤代烃与格氏试剂的苄基化和烯丙基化反应。

Silver-catalyzed benzylation and allylation reactions of tertiary and secondary alkyl halides with grignard reagents.

作者信息

Someya Hidenori, Ohmiya Hirohisa, Yorimitsu Hideki, Oshima Koichiro

机构信息

Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

出版信息

Org Lett. 2008 Mar 6;10(5):969-71. doi: 10.1021/ol800038a. Epub 2008 Feb 2.

DOI:10.1021/ol800038a

PMID:18247499

Abstract

Treatment of alkyl halides, including tertiary alkyl bromides, with benzylic or allylic Grignard reagent in the presence of a catalytic amount of silver nitrate in ether yielded the corresponding cross-coupling products in high yields. The coupling reactions of tertiary alkyl halides provide efficient access to quaternary carbon centers.

摘要

在醚中，在催化量的硝酸银存在下，用苄基或烯丙基格氏试剂处理卤代烷，包括叔烷基溴，可高产率地得到相应的交叉偶联产物。叔烷基卤的偶联反应为构建季碳中心提供了有效途径。