Walter Ronald B, Ju Zhenlin, Martinez Al, Amemiya Chris, Samollow Paul B
Molecular Biosciences Research Group, Department of Chemistry and Biochemistry, Texas State University, San Marcos, Texas 78666-4616, USA.
Zebrafish. 2006;3(1):11-22. doi: 10.1089/zeb.2006.3.11.
Xiphophorus fishes and interspecies hybrids are used in many areas of contemporary research. Due to their high degree of heterozygosity Xiphophorus interspecies hybrids are extremely valuable models for molecular genetic study of gene regulation in physiology and behavior. Historically, Xiphophorus fish have made a contribution to understanding the genetics underlying tumorigenesis but the role this experimental model system may play in contemporary comparative biology has only just begun to be realized. In spite of many advantages a genome-level Xiphophorus sequencing project has not yet been initiated. In order to set a stage for a genome-level initiative, many Xiphophorus resources have recently been, or are currently being developed. Recent completion of the Xiphophorus gene linkage map, construction of microsatellite marker and EST databases, and the accessibility of BAC library resources hallmark the progress in development of genomic capabilities for Xiphophorus investigations. Herein we review current Xiphophorus genomic resources and to provide the reader with information that will enable them to access these resources available to enhance their investigations.
剑尾鱼属鱼类及其种间杂种在当代研究的许多领域都有应用。由于剑尾鱼属种间杂种具有高度杂合性，它们是生理学和行为学中基因调控分子遗传学研究的极有价值的模型。从历史上看，剑尾鱼属鱼类对理解肿瘤发生的遗传学基础做出了贡献，但这个实验模型系统在当代比较生物学中可能发挥的作用才刚刚开始被认识到。尽管有许多优点，但剑尾鱼属的全基因组测序项目尚未启动。为了为全基因组计划奠定基础，最近已经或正在开发许多剑尾鱼属资源。剑尾鱼属基因连锁图谱的近期完成、微卫星标记和EST数据库的构建以及BAC文库资源的可获取性标志着剑尾鱼属研究基因组能力发展的进展。在此，我们综述了当前剑尾鱼属的基因组资源，并为读者提供信息，使他们能够获取这些可用资源以加强他们的研究。
