Department of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Acta Paediatr. 2012 Aug;101(8):e321-6. doi: 10.1111/j.1651-2227.2012.02694.x. Epub 2012 May 2.
To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age.
Infants born <32 weeks' gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC-MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis.
Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age.
Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.
验证早产儿血浆脂质代谢物水平与支气管肺发育不良（BPD）发展相关的假设。研究还检验了血浆脂质代谢物水平与胎龄相关的次要假设。
在出生后 72 小时内，纳入胎龄<32 周的婴儿。采集血浆样本，通过 LC-MS/MS 测量脂质水平。收集临床数据以确定婴儿结局和 BPD 诊断。
在调整混杂因素后，脂质水平与 BPD 无关；然而，特定脂质代谢物的水平与胎龄相关。
早产儿不成熟的脂质代谢途径可能导致 BPD 和其他疾病的发病机制。
