血浆脂质代谢物与胎龄相关，但与支气管肺发育不良无关。
Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.
机构信息
Department of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
出版信息
Acta Paediatr. 2012 Aug;101(8):e321-6. doi: 10.1111/j.1651-2227.2012.02694.x. Epub 2012 May 2.
Abstract
AIM
To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age.
METHODS
Infants born <32 weeks' gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC-MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis.
RESULTS
Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age.
CONCLUSION
Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.
摘要
目的
验证早产儿血浆脂质代谢物水平与支气管肺发育不良（BPD）发展相关的假设。研究还检验了血浆脂质代谢物水平与胎龄相关的次要假设。
方法
在出生后 72 小时内，纳入胎龄<32 周的婴儿。采集血浆样本，通过 LC-MS/MS 测量脂质水平。收集临床数据以确定婴儿结局和 BPD 诊断。
结果
在调整混杂因素后，脂质水平与 BPD 无关；然而，特定脂质代谢物的水平与胎龄相关。
结论
早产儿不成熟的脂质代谢途径可能导致 BPD 和其他疾病的发病机制。
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