Head Elizabeth, Rofina Jaime, Zicker Steven
Institute for Brain Aging and Dementia, Department of Neurology, University of California at Irvine, 1259 Gillespie Neuroscience Research Facility, Irvine, CA 92697-4540, USA.
Vet Clin North Am Small Anim Pract. 2008 Jan;38(1):167-78, vi. doi: 10.1016/j.cvsm.2007.10.002.
Decline in cognitive functions that accompany aging in dogs may have a biologic basis, and many of the disorders associated with aging in dogs may be mitigated through dietary modifications that incorporate specific nutraceuticals. Based on previous research and the results of laboratory and clinical studies, antioxidants may be one class of nutraceutical that provides benefits to aged dogs. Brains of aged dogs accumulate oxidative damage to proteins and lipids, which may lead to dysfunction of neuronal cells. The production of free radicals and lack of increase in compensatory antioxidant enzymes may lead to detrimental modifications to important macromolecules within neurons. Reducing oxidative damage through food ingredients rich in a broad spectrum of antioxidants significantly improves, or slows the decline of, learning and memory in aged dogs.
犬类衰老过程中伴随的认知功能衰退可能有生物学基础，并且许多与犬类衰老相关的疾病可以通过包含特定营养保健品的饮食调整来缓解。基于先前的研究以及实验室和临床研究结果，抗氧化剂可能是一类对老龄犬有益的营养保健品。老龄犬的大脑会积累蛋白质和脂质的氧化损伤，这可能导致神经元细胞功能障碍。自由基的产生以及代偿性抗氧化酶缺乏增加可能会导致神经元内重要大分子发生有害修饰。通过富含多种抗氧化剂的食物成分减少氧化损伤，可显著改善老龄犬的学习和记忆能力，或减缓其衰退。
