Siengsukon Catherine F, Boyd Lara A
Department of Physical Therapy and Rehabilitation Science, University of Kansas Medical Center, Kansas City, Kansas, USA.
Top Stroke Rehabil. 2008 Jan-Feb;15(1):1-12. doi: 10.1310/tsr1501-1.
Although sleep has been demonstrated to be critical for learning and the consolidation of memories in neurologically intact individuals, the importance of sleep for learning in neuropathological populations remains unknown.
To assess the influence of sleep on implicit motor skill learning and memory consolidation post stroke, 18 individuals with stroke and 18 neurologically intact age-matched individuals were assigned to either the sleep group (slept between practice of a continuous tracking task and retention testing) or the no-sleep group (stayed awake between practice and retention testing).
Only the individuals post stroke who slept between practice and retention testing demonstrated implicit motor learning at retention. The individuals with stroke who did not sleep and both the age-matched control groups (sleep and no-sleep) failed to demonstrate learning. These findings provide evidence that after stroke individuals can enhance implicit motor skill learning and motor memory consolidation by sleeping between practice and retention tests.
These data suggest that ensuring adequate sleep between rehabilitation therapy sessions and normalizing sleep cycles following stroke may be important variables that can positively influence implicit motor learning after stroke-related brain damage.
尽管睡眠已被证明对神经功能正常个体的学习和记忆巩固至关重要，但睡眠对神经病理学人群学习的重要性仍不明确。
为评估睡眠对中风后内隐运动技能学习和记忆巩固的影响，将18名中风患者和18名年龄匹配的神经功能正常个体分为睡眠组（在连续跟踪任务练习和保持测试之间睡眠）或无睡眠组（在练习和保持测试之间保持清醒）。
只有在练习和保持测试之间睡眠的中风后个体在保持测试时表现出内隐运动学习。未睡眠的中风患者以及两个年龄匹配的对照组（睡眠组和无睡眠组）均未表现出学习。这些发现提供了证据，表明中风后个体可通过在练习和保持测试之间睡眠来增强内隐运动技能学习和运动记忆巩固。
这些数据表明，确保康复治疗期间有充足睡眠以及使中风后的睡眠周期正常化可能是对中风相关脑损伤后内隐运动学习产生积极影响的重要变量。
