Takayanagi I, Kondo N, Takagi K
Eur J Pharmacol. 1976 Jul;38(1):179-82. doi: 10.1016/0014-2999(76)90215-6.
The maximum contraction induced in taenia from the guninea pig caecum by a cholinergic stimulant, butyltrimethylammonium (BuTMA) was relaxed by papaverine (10(-4) M) but not by l-isoprenaline (5 X 10(-7) M). The concentrations used relaxed the taenia completely in the absence of BuTMA. BuTMA (10(-4) M) decreased the increase of cyclic AMP caused by isoprenaline but not that due to papaverine. Futhermore, photoinactivation of the beta-adrenoceptors by l-isoprenaline was not observed on the taenia contracted by BuTMA (10(-4) M). These results suggest that l-isoprenaline does nto interact with the beta-adrenoceptors in the taenie contracted by the high concentration of BuTMA.
豚鼠盲肠带绦虫经胆碱能兴奋剂丁基三甲基铵（BuTMA）诱导产生的最大收缩，可被罂粟碱（10⁻⁴M）松弛，但不能被l - 异丙肾上腺素（5×10⁻⁷M）松弛。在不存在BuTMA的情况下，所使用的浓度可使带绦虫完全松弛。BuTMA（10⁻⁴M）可降低异丙肾上腺素引起的环磷酸腺苷（cAMP）增加，但不影响罂粟碱引起的cAMP增加。此外，在由BuTMA（10⁻⁴M）收缩的带绦虫上未观察到l - 异丙肾上腺素对β - 肾上腺素能受体的光灭活作用。这些结果表明，l - 异丙肾上腺素不与高浓度BuTMA收缩的带绦虫中的β - 肾上腺素能受体相互作用。
