生长抑素类似物对前列腺素诱导的大鼠体外垂体前叶环磷酸腺苷积累的拮抗作用。
Antagonism of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary in vitro by somatostatin analogues.
作者信息
Lippmann W, Sestanj K, Nelson V R, Immer H U
出版信息
Experientia. 1976 Aug 15;32(8):1034-6. doi: 10.1007/BF01933956.
PMID:182523
Abstract
The PGE2-induced cyclic AMP accumulation in the rat anterior pituitary in vitro is inhibited by [desamino1]-[desamino1] [descarboxy14]- and [D-Lys4]-somatostatin similarly to somatostatin, while the [descarboxy14]-somatostatin exhibits reduced activity; [D-Lys9]-somatostatin is ineffective at a higher concentration.
摘要
与生长抑素类似，[去氨基1]-[去氨基1][去羧基14]-和[D-赖氨酸4]-生长抑素可抑制体外培养的大鼠垂体前叶中前列腺素E2诱导的环磷酸腺苷积累，而[去羧基14]-生长抑素的活性降低；[D-赖氨酸9]-生长抑素在较高浓度时无效。
Zotero 插件