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阿来他汀对前列腺素诱导的大鼠垂体前叶环磷酸腺苷积累的抑制作用。

Inhibition of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary by alrestatin.

作者信息

Lippmann W

出版信息

Experientia. 1978 Apr 15;34(4):441-3. doi: 10.1007/BF01935914.

DOI:10.1007/BF01935914
PMID:205429
Abstract

Alrestatin at 25-1 X 10(-4) M inhibited the accumulation of cyclic AMP induced by prostaglandin E2, but not theophylline, in the rat anterior pituitary in vitro. Somatostatin, at lower concentrations, inhibited both; maximal inhibition of the prostaglandin effect was greater with alrestatin. As cyclic AMP is considered to be a mediator in induced-hormonal release, it appears from the present findings that alrestatin may be of potential use in altering hormonal release.

摘要

在体外实验中，25 - 1×10⁻⁴M的阿勒他汀抑制了前列腺素E2诱导的大鼠垂体前叶中环状AMP的积累，但不抑制茶碱诱导的积累。较低浓度的生长抑素对两者都有抑制作用；阿勒他汀对前列腺素作用的最大抑制作用更强。由于环状AMP被认为是诱导激素释放的介质，从目前的研究结果来看，阿勒他汀可能在改变激素释放方面具有潜在用途。

相似文献

1
Inhibition of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary by alrestatin.阿来他汀对前列腺素诱导的大鼠垂体前叶环磷酸腺苷积累的抑制作用。
Experientia. 1978 Apr 15;34(4):441-3. doi: 10.1007/BF01935914.
2
Antagonism of prostaglandin-induced cyclic AMP accumulation in the rat anterior pituitary in vitro by somatostatin analogues.生长抑素类似物对前列腺素诱导的大鼠体外垂体前叶环磷酸腺苷积累的拮抗作用。
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3
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Experientia. 1977 Jan 15;33(1):61-3. doi: 10.1007/BF01936755.
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A comparison of the effects of PGI2, PGE2 and PGH2 on the cyclic nucleotide levels in rat anterior pituitary gland in vitro.
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本文引用的文献

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Synthesis of somatostatin.生长抑素的合成。
Helv Chim Acta. 1974 Apr 27;57(3):730-4. doi: 10.1002/hlca.19740570326.
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Inhibition of growth hormone and thyrotropin release by growth hormone-release inhibiting hormone.生长激素释放抑制激素对生长激素和促甲状腺激素释放的抑制作用。
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Phosphodiesterase in tongue epithelium: activation by bitter taste stimuli.舌上皮中的磷酸二酯酶：苦味刺激的激活作用。
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Stimulation of adenosine 3':5'-cyclic monophosphate accumulation in anterior pituitary gland in vitro by synthetic luteinizing hormone-releasing hormone.合成促黄体生成素释放激素对体外培养的垂体前叶中3':5'-环磷酸腺苷积累的刺激作用。
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Studies on growth hormone secretion. 3. Inhibition of prostaglandin, theophylline and cyclic amp stimulated growth hormone release by valinomycin in vitro.
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Studies on growth hormone secretion. II. Stimulation by prostaglandins in vitro.生长激素分泌的研究。II. 前列腺素在体外的刺激作用。
Acta Endocrinol (Copenh). 1971 Oct;68(2):355-62. doi: 10.1530/acta.0.0680355.
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Actinomycin-insensitive stimulation of protein synthesis in rat anterior pituitary in vitro by dibutyryl adenosine 3',5'-monophosphate.
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Release of pituitary growth hormone by prostaglandins and dibutyryl adenosine cyclic 3':5'-monophosphate in the absence of protein synthesis.在缺乏蛋白质合成的情况下，前列腺素和二丁酰腺苷环3',5'-单磷酸对垂体生长激素的释放作用
Proc Natl Acad Sci U S A. 1970 Nov;67(3):1172-9. doi: 10.1073/pnas.67.3.1172.