Colosio C, Tomasini M, Cairoli S, Foà V, Minoia C, Marinovich M, Galli C L
Istituto di Medicina del Lavoro, Università degli Studi di Milano, Italia.
Br J Ind Med. 1991 Feb;48(2):136-9. doi: 10.1136/oem.48.2.136.
A case of triphenyltin acetate (TPTA) poisoning is described. The patient, who had been exposed mainly to cutaneous absorption, showed acute stages of an urticarial eruption, signs of hepatic injury, slight glucose intolerance, and electroencephalographic abnormalities. Concomitant with the highest concentrations of tin in plasma and the peak of tin excretion in urine, neutrophils did not show the normal increase in actin polymerisation after stimulation with a chemotactic peptide (100 nM fMLP). The peak of urinary excretion of tin occurred between the fifth and the sixth day after poisoning; subsequently, the rate of excretion became slow, suggesting biphasic kinetics with the possibility of a cumulative trend.
本文描述了一例醋酸三苯基锡（TPTA）中毒病例。该患者主要通过皮肤接触吸收，表现出急性荨麻疹期、肝损伤迹象、轻度葡萄糖耐量异常和脑电图异常。在血浆中锡浓度最高和尿中锡排泄达到峰值时，用趋化肽（100 nM fMLP）刺激后，中性粒细胞肌动蛋白聚合未出现正常增加。锡的尿排泄峰值出现在中毒后第五天至第六天之间；随后，排泄速率变慢，提示存在双相动力学且可能有累积趋势。
