Edwards Kate M, Burns Victoria E, Adkins Alison E, Carroll Douglas, Drayson Mark, Ring Christopher
School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, B15 2TT, UK.
Psychosom Med. 2008 Feb;70(2):147-51. doi: 10.1097/PSY.0b013e318164232e. Epub 2008 Feb 6.
To determine if acute stress experienced at the time of antigenic challenge augments the subsequent immune response.
Sixty healthy young adults were randomized to exercise (n = 20), mental stress (n = 20) or control (n = 20) before meningococcal A+C vaccination. Antibody concentration was measured by microsphere-based antibody quantification assay at prevaccination, 4 and 20 weeks post vaccination.
Meningococcal serogroup A antibody responses were enhanced by exercise and mental stress in men but not women (F(2,51) = 4.00, p = .02, eta(2) = 0.135).
Stress-induced immune enhancement has now been demonstrated in the antibody response to thymus-independent as well as thymus-dependent vaccines. These findings indicate that this effect is not specific to T-cell involvement.
确定抗原激发时经历的急性应激是否会增强随后的免疫反应。
60名健康的年轻成年人在接种A+C群脑膜炎球菌疫苗前被随机分为运动组（n = 20）、精神应激组（n = 20）或对照组（n = 20）。在接种疫苗前、接种后4周和20周，通过基于微球的抗体定量测定法测量抗体浓度。
运动和精神应激增强了男性对A群脑膜炎球菌的抗体反应，但女性没有（F(2,51) = 4.00，p = .02，eta(2) = 0.135）。
应激诱导的免疫增强现已在对非胸腺依赖性及胸腺依赖性疫苗的抗体反应中得到证实。这些发现表明这种效应并非特异性地涉及T细胞。
