Reuzel P G, Dreef-van der Meulen H C, Hollanders V M, Kuper C F, Feron V J, van der Heijden C A
TNO-CIVO Toxicology and Nutrition Institute, Zeist, The Netherlands.
Food Chem Toxicol. 1991 Jan;29(1):31-9. doi: 10.1016/0278-6915(91)90060-k.
The toxicity and carcinogenicity of methyl bromide (MeBr) were studied in male and female Wistar rats exposed by inhalation to 0, 3, 30 or 90 ppm MeBr 6hr/day, 5 days/wk for 29 months. After 13, 52 and 104 wk ten rats/sex/group were killed to provide interim information. Body weights, clinical signs, haematology, biochemistry and gross and microscopic pathology were studied. Mortality was increased by wk 114 in the 90-ppm group. Body weights in males and females of the 90-ppm group were lower than those of the controls throughout the study. Increased incidences of degenerative and hyperplastic changes of the nasal olfactory epithelium were observed in all exposed groups, the incidences being positively correlated with the MeBr concentration; the nasal lesions did not progress appreciably with time. Exposure to 90 ppm MeBr was associated with an increased incidence of lesions in the heart (thrombi, myocardial degeneration), and with hyperkeratosis in the oesophagus and forestomach. Data on site, type and incidence of tumours in the various groups did not indicate carcinogenic activity of MeBr.
对雄性和雌性Wistar大鼠进行了甲基溴（MeBr）的毒性和致癌性研究，这些大鼠每天吸入0、3、30或90 ppm的MeBr，每周5天，每天6小时，持续29个月。在第13、52和104周时，每组处死10只/性别的大鼠以提供中期信息。研究了体重、临床体征、血液学、生物化学以及大体和微观病理学。在第114周时，90 ppm组的死亡率增加。在整个研究过程中，90 ppm组雄性和雌性大鼠的体重均低于对照组。在所有暴露组中均观察到鼻嗅上皮退行性和增生性变化的发生率增加，其发生率与MeBr浓度呈正相关；鼻部病变并未随时间明显进展。暴露于90 ppm MeBr与心脏病变（血栓、心肌变性）的发生率增加以及食管和前胃的角化过度有关。各实验组肿瘤的发生部位、类型和发生率的数据未表明MeBr具有致癌活性。
