Zioncheck T F, Powell L M, Rice G C, Eaton D L, Lawn R M
Department of Cardiovascular Research, Genetech, Inc., South San Francisco, California 94080.
J Clin Invest. 1991 Mar;87(3):767-71. doi: 10.1172/JCI115079.
Elevated plasma levels of lipoprotein(a), Lp(a), represent a major, inherited risk factor for coronary heart disease, although the mechanism of its action remains unknown. Lp(a) is distinguished from the related LDL particle by the addition of apolipoprotein(a), apo(a). The presence of this large glycoprotein is likely to affect the binding of the particle to the LDL receptor and/or other receptors which may contribute to the atherogenic potential of Lp(a). Here we demonstrate the binding to macrophages of Lp(a) and pure recombinant apo(a) protein, via a specific, high-affinity receptor. This binding could lead to foam cell formation and the localization of Lp(a) to atherosclerotic plaques.
脂蛋白(a) [Lp(a)] 的血浆水平升高是冠心病的一个主要遗传性危险因素,尽管其作用机制尚不清楚。Lp(a) 通过添加载脂蛋白(a) [apo(a)] 与相关的低密度脂蛋白(LDL)颗粒区分开来。这种大糖蛋白的存在可能会影响该颗粒与LDL受体和/或其他受体的结合,这可能会增加Lp(a) 的动脉粥样硬化形成潜力。在这里,我们证明了Lp(a) 和纯重组apo(a) 蛋白通过一种特异性高亲和力受体与巨噬细胞结合。这种结合可能导致泡沫细胞形成以及Lp(a) 在动脉粥样硬化斑块中的定位。