人类载脂蛋白(a)的cDNA序列与纤溶酶原同源。
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.
作者信息
McLean J W, Tomlinson J E, Kuang W J, Eaton D L, Chen E Y, Fless G M, Scanu A M, Lawn R M
机构信息
Department of Cardiovascular Research, Genentech, Inc., South San Francisco, California 94080.
出版信息
Nature. 1987;330(6144):132-7. doi: 10.1038/330132a0.
Lipoprotein(a) is an LDL-like lipoprotein whose concentration in plasma is correlated with atherosclerosis. The characteristic protein component of lipoprotein(a) is apolipoprotein(a) which is disulphide-linked to apolipoprotein B-100. Sequencing of cloned human apolipoprotein(a) complementary DNA shows that it is very similar to human plasminogen. It contains a serine protease domain and two types of plasminogen-like kringle domains, one of which is present in 37 copies.
脂蛋白(a)是一种类似低密度脂蛋白（LDL）的脂蛋白，其在血浆中的浓度与动脉粥样硬化相关。脂蛋白(a)的特征性蛋白质成分是载脂蛋白(a)，它通过二硫键与载脂蛋白B-100相连。克隆的人载脂蛋白(a)互补DNA的测序表明，它与人纤溶酶原非常相似。它包含一个丝氨酸蛋白酶结构域和两种类型的纤溶酶原样kringle结构域，其中一种以37个拷贝存在。
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