对原发性免疫缺陷患者及供体的人外周血单核细胞体外Toll样受体依赖性促炎细胞因子产生情况的分析
Analysis of toll-like receptor-dependent production of proinflammatory cytokines in vitro by human peripheral blood mononuclears of donors and patients with primary immunodeficiency.
作者信息
Koval'chuk L V, Khoreva M V, Varivoda A S, Pashchenko O E, Gracheva L A, Bykova L P, Kondratenko I V, Bologov A A
机构信息
Russian State Medical University, Moscow.
出版信息
Bull Exp Biol Med. 2007 Jul;144(1):63-5. doi: 10.1007/s10517-007-0255-z.
The production of TNF-alpha and IFN-alpha cytokines by peripheral blood mononuclears in response to stimulation by TLR2/6, TLR4, TLR5, TLR9 ligands (zymosan, LPS, flagellin, and CpG-oligodeoxynucleotide, respectively) was studied in donors and patients with common variable immunodeficiency. Individual characteristics of TNF-alpha production by mononuclears were revealed in donors. Reduced stimulated production of TNF-alpha in response to stimulation with TLR4 and TLR5 ligands in vitro was detected in patients with common variable immunodeficiency.
在普通可变免疫缺陷的供体和患者中，研究了外周血单核细胞对TLR2/6、TLR4、TLR5、TLR9配体（分别为酵母聚糖、脂多糖、鞭毛蛋白和CpG-寡脱氧核苷酸）刺激的反应中TNF-α和IFN-α细胞因子的产生。在供体中揭示了单核细胞产生TNF-α的个体特征。在普通可变免疫缺陷患者中，检测到体外对TLR4和TLR5配体刺激的TNF-α刺激产生减少。
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