Messner M C, Albert C J, McHowat J, Ford D A
Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, MO 63104, USA.
Lipids. 2008 Mar;43(3):243-9. doi: 10.1007/s11745-008-3151-z. Epub 2008 Feb 7.
Lysophosphatidylcholine (LysoPtdCho) levels are elevated in sera in patients with atherosclerosis and in atherosclerotic tissue. Previous studies have shown that reactive chlorinating species attack plasmalogens in human coronary artery endothelial cells (HCAEC), forming lysoPtdCho and lysoPtdCho-chlorohydrin (lysoPtdCho-ClOH). The results herein demonstrate for the first time that lysoPtdCho-ClOH is elevated over 60-fold in human atherosclerotic lesions. In cultured HCAEC, 18:0 lysoPtdCho-ClOH led to a statistically significant increase in P-selectin cell-surface expression, but unlike 18:1 lysoPtdCho did not lead to cyclooxygenase-2 protein expression. These data show that 18:0 lysoPtdCho-ClOH is elevated in atherosclerotic tissue and may have unique pro-atherogenic properties compared to lysoPtdCho.
溶血磷脂酰胆碱(LysoPtdCho)水平在动脉粥样硬化患者的血清和动脉粥样硬化组织中升高。先前的研究表明,活性氯化物质攻击人冠状动脉内皮细胞(HCAEC)中的缩醛磷脂,形成溶血磷脂酰胆碱和溶血磷脂酰胆碱氯醇(lysoPtdCho-ClOH)。本文的结果首次证明,lysoPtdCho-ClOH在人类动脉粥样硬化病变中升高超过60倍。在培养的HCAEC中,18:0 lysoPtdCho-ClOH导致P-选择素细胞表面表达有统计学意义的增加,但与18:1溶血磷脂酰胆碱不同,它不会导致环氧合酶-2蛋白表达。这些数据表明,18:0 lysoPtdCho-ClOH在动脉粥样硬化组织中升高,与溶血磷脂酰胆碱相比可能具有独特的促动脉粥样硬化特性。