Bombelli Cecilia, Bernardini Carlotta, Elemento Gioia, Mancini Giovanna, Sorrenti Alessandro, Villani Claudio
CNR, Istituto di Metodologie Chimiche and Dipartimento di Chimica "La Sapienza", P.le A. Moro 5, 00185 Roma, Italy.
J Am Chem Soc. 2008 Mar 5;130(9):2732-3. doi: 10.1021/ja710687e. Epub 2008 Feb 8.
Chiral recognition was observed in a biomembrane model. Micellar aggregates formed by enantiopure N-alkyl-N,N-dimethyl-N-(1-phenyl)ethylammonium bromide were in fact able to convert the racemic mixture of bilirubin-IXalpha into an enantiomerically enriched mixture. The stereochemical preference and the extent of enantiomeric enrichment depend on the length of the hydrophobic portion of the surfactant and on the concentration conditions, and changes in the stereochemical bias are reversible.
在生物膜模型中观察到了手性识别。对映体纯的N-烷基-N,N-二甲基-N-(1-苯基)乙铵溴化物形成的胶束聚集体实际上能够将胆红素-IXα的外消旋混合物转化为对映体富集混合物。立体化学偏好和对映体富集程度取决于表面活性剂疏水部分的长度和浓度条件，并且立体化学偏差的变化是可逆的。
