Okutani Masaru, Mori Yuji
Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.
J Org Chem. 2009 Jan 2;74(1):442-4. doi: 10.1021/jo802101a.
Tetra-n-butylammonium fluoride was found to be a mild and efficient base for the elimination reaction of bromoalkenes. Treatment of 1,1-dibromoalkenes, (Z)-1-bromoalkenes, and internal bromoalkenes with 5 equiv of TBAF x 3H2O in DMF yielded terminal and internal alkynes in high yields without undue regard to the presence of water.
发现四丁基氟化铵是用于溴代烯烃消除反应的温和且高效的碱。在N,N-二甲基甲酰胺中用5当量的四丁基氟化铵三水合物处理1,1-二溴烯烃、(Z)-1-溴烯烃和内溴烯烃，可高收率地得到末端和内炔烃，而无需过多考虑水的存在。
