Mayr A, Danner K
Dev Biol Stand. 1976;33:249-59.
Oral vaccination against fowl pox is both effective and harmless. A suitable vaccine strain is the attenuated HP-1 strain in the 200th to 400th tissue culture passage. For optimal immunization virus of the 200th to 270th passage level should be applied twice at an interval of 3 to 4 weeks. Vaccination dose should contain 10(7.0)TCID50. Chickens may be effectively immunized already at 5 days. Immunity is against both homologous and heterologous virus and proves equally resistant to oral, cutaneous and intravenous challenge. Protection of mucous membranes of the upper respiratory and digestive tract forms faster than after cutaneous immunization. Compared to conventional fowl pox vaccination, drinking water vaccination facilitates the technicalities of vaccination; there are immunological advantages and risks of complications are avoided. It can therefore be recommended as a model for vaccination against smallpox in man.
口服鸡痘疫苗既有效又无害。合适的疫苗株是在第200至400代组织培养传代中的减毒HP - 1株。为获得最佳免疫效果，应使用第200至270代传代水平的病毒，间隔3至4周接种两次。疫苗剂量应含有10(7.0)TCID50。雏鸡在5日龄时即可有效免疫。该免疫对同源和异源病毒均有效，且对口服、皮肤和静脉内攻击均表现出同等抗性。上呼吸道和消化道黏膜的保护形成速度比皮肤免疫后更快。与传统鸡痘疫苗接种相比，饮水免疫简化了接种技术；具有免疫学优势且避免了并发症风险。因此，它可被推荐作为人类天花疫苗接种的模型。
